All wheels flex somewhat during cornering. And big sticky tires will flex the wheels more than smaller tires due to the enhanced traction. Suggest making VERY sure there's at least 1/4" of clearance between the valve and any hard spots within range. Knocking a valve off at speed could ruin more than just your day....
Those big tires will also cause body flex for the same reasons. Chassis braces and especially a proper bay brace that reaches all the way back into the welded pockets of your inner rear fenders may help prevent paint (and fender panel) cracking.
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