Reply to "Large Diameter Campy Clones available from American Republic Wheels"

All wheels flex somewhat during cornering. And big sticky tires will flex the wheels more than smaller tires due to the enhanced traction. Suggest making VERY sure there's at least 1/4" of clearance between the valve and any hard spots within range. Knocking a valve off at speed could ruin more than just your day....
Those big tires will also cause body flex for the same reasons. Chassis braces and especially a proper bay brace that reaches all the way back into the welded pockets of your inner rear fenders may help prevent paint (and fender panel) cracking.
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