Actually the 1st mid engine road car was Henry Ford's 1st car, the Quadricycle, back in 1896. It had a 2-speed transmission and it ran on Ethanol. They sold for $200, which was very expensive back in the day.
It was folowed by Ford's mid-engine "Sweepstakes " race cars in 1901:
Which evolved into Ford's "first" Model A, which was also mid-engine. Ford sold 1,750 of them in 1903-04.