Not to my knowledge, but I could be wrong.
The 2v heads have a torque advantage at lower engine rpm's due to the smaller port area cross sections.
I've seen them run very well on 302's also.
The 2v heads are also pretty much limited to a .500" lift cam. They simply stop flowing over that.
In order to make 500hp out of 351 inches, you need around a .600" lift with 4v heads too...but this is kinda sidetracking this thread isn't it?