Its always more difficult working on the heads installed on the engine rather than working on them on a bench, but it is possible. I don't recommend doing any spring pedestal machining however because of the iron filings it creates. So limitations in what work you can do, and increased difficulty are the two drawbacks.
There are tools for compressing the springs from the top-side, making it possible to remove & install them. The trick to preventing the valves from falling into the engine once the springs are removed is to place the cylinder you're working on at top dead center.
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