"Is there anything tricky about doing a 4 wheel alignment on the Pantera? "
Panteras are not particularly difficult to align unless the car has damage to the frame and/or suspension. There is also the factor that the cars are nearly 50 years old and some of the cars have rusty or frozen suspension bolts that have not been turned since installation at the factory.
"Can your average mechanic do it?"
It's possible, but probably not. A typical tire shop that aligns our commuter cars is on a tight schedule. If your car's suspension has been methodically rebuilt and everything is fresh and clean then the answer is yes. Nonetheless, when they see a Pantera they will probably turn you away. There are some alignment shops that are setup to work on classic cars and should be able to make it happen but the cost will be higher.
What is your car's suspension like? Original or rebuilt? Is the car pulling? Is there play in the steering rack? Is the steering wheel centered? Do you have uneven tire wear? Sorry for so many questions, just describe what you know.