Johnny,
Covering the subject of stroker motors & engine response (acceleration of the reciprocating assembly) involves discussing the very basics of IC engine design, in other words, a lot of material, more than what I'm willing to type in one sitting. Here are some random thoughts that come to mind:
Piston speed is one of the factors that will limit a motor's rpm potential. A piston stroking 3.00" at 6000 rpm is traveling slower than a piston stroking 4.00" at the same rpm. So the question is, is the piston speed of a 4.00" stroker enough to limit the rpm potential of a motor to only 6000 rpm, the answer is no.
Another factor is the connecting rod length to stroke ratio. Basically a performance street motor wants a Rod to Stroke ratio of 1.55:1 or higher to reduce side loading force on the thrust side of the piston to minimize friction. This becomes more critical above 5500rpm. The factory Chevy 400 had really short 5.565 rods and a 3.750 stroke having a 1.48:1 ratio. This motor works fine to 5500rpm, then you can experience a hard or harsh feeling for the motor, not vibration but kind of like it. By putting 5.700 rods in this motor it will happily buzz over 6000RPM with a 1.52:1 ratio.
A 4.00" stroke with a 6.00" rod is a rod to stroke ratio of exactly 1.5:1. Where this limits the Cleveland, or any motor, I have no experience, I've never built a 4.00" stroker. There are guys, such as Kelly Coffield (Panterror) running that combination, perhaps he or someone else can chime in.
In your case, running a 9.5" deck (?) Windsor block, you can run a 6.2" rod (common size) giving you a ratio of 1.55:1. If you intersect the oil ring groove with the wrist pin, you could run a 6.4" rod giving a ratio of 1.6:1. That would be my recommendation if you truly feel you need to rev the stroker motor to 7500 rpm.
On the subject of responsiveness of the engine, the weight of a reciprocating assembly, the frictional forces, the piston speed, the rod to stroke ratio, all these factors come into play, but a good generalization is of course, short stroke motors are more "responsive" than longer stroke motors, but increasing the stroke from 3.5" to 4.00" will not affect dynnamic response to the detriment of the acceleration of a road going Panterra. The difference would be noticable in a F1 vehicle, not in a 3000 lb Pantera.
The point with stroker motors is building more torque at a lower rpm (like Charlie wrote). The end goal is to accelerate the vehicle, so what I want to do is steer your thoughts to thinking of the vehicle as a whole system. The increased power of the motor will quicken the 0 to 60 acceleration rate of your Pantera, even though it will have a longer stroke. This is because other things also affect the acceleration of your car, such as vehicle weight, the weight of rotating parts, drive train friction, the traction of the rear tires, clutch slippage, the DRIVER, etc. Other things you can do to "quicken" the response of your "car" (I did not write motor, I wrote car intentionally) is add a lightened flywheel, or run light weight 3 piece wheels instead of one piece cast or billet wheels, add 3.77:1 final drive gears in the ZF (Charlie's advice).
My advice for a strong street motor is to shoot for a powerband of 2000 to 6000 rpm, with a red line of 6500 rpm. This is easy to achieve, and easy on the motor, and with 427 cubic inches it will be easier to maintain control of the vehicle and provide plenty of acceleration.
On the other hand, if high revving is what is most fun for you, keep the 3.5" stroke and just build a strong, high revving 351 cubic inch motor. A well built Cleveland will take repeated blasts to 7500 rpm with no drama, just a lot of grins, I know, been there, done that. It is easy to hit the 450 bhp mark with a 351 cubic inch motor, I was doing that back in the '70s & '80s, with todays parts you could surely do better.
Just the random thoughts of an old beggar.
By the way Charlie, it's always a pleasure when you contribute. I wish more long time owners were active here on the DTBB, sharing their experience with the Pantera.
your friend on the DTBB, George