Josh,
Keep in mind there are many alloy heads available for the 351C. If I focus my answer to the products manufactured by AFD & CHI, the answer is YES and MAYBE.
AFD uses a uni-exhaust port for both their 2V & 4V heads, supposed to be small enough for 2V header flanges, definitely OK for 4V header flanges, stock bolt pattern, the port is raised 2mm (0.080"), which should be no problem.
CHI uses a true uni-exhaust port with their 2V & 4V heads, it is in the stock location, stock bolt pattern and is again supposed to be small enough for 2V header flanges, definitely OK for 4V header flanges.
CHI employs a 0.400" raised exhaust port on their 3V cylinder heads, the headers will be raised and moved outboard a small amount, this may create a chassis fitment problem with some headers or it may not. Other than that, the exhaust port employs the stock bolt pattern and is definitely small enough to fit 4V header flanges with no problems, I think 2V header flanges require a bit of grinding. This is all from memory, you know how that goes...
heres the links:
http://www.airflowdynamics.com.au/http://www.chiheads.com/cowboy from hell