Cab-
This might give you a baseline.
I have run 4V, big-valve/big-port closed-chambered 'quench' heads measureing out at 62.4 cc with flat-topped pistons which 'the book' says will give +- 10.50 to 11.00. And running on our 95 octane pumpgas here with a mild Hyd. cam have encountered no problems at all. The 'quench' closed-chambered hds. do allow higher compression due to the cooling of the mixture as the flame front gets "quenched" travelling across the chamber & due to the more efficent burn of these heads. They are the way to go if u are looking for middle to top end use. But if u are looking at relatively 'normal' stoplite dragging, useing more bottom-end torque, then the smaller ports / valves of the 2V hds., with their higher velocity thru the narrower, smaller ports are the way to go I feel. IMHO.