Stumbled upon this on the Net, The Wife was disturbed by it...So I had to Post It!! A Rarely Known Middle Name. I always Liked this Cartoon because I Enjoy the Mojave Desert.
When Chuck Jones was creating the character of Wile. E Coyote, he found inspiration in the writings of renowned author Mark Twain. In his 1872 novel Roughing It, he describes the coyote as "long, slim, sick and sorry-looking skeleton [...] a living, breathing allegory of Want. He is always hungry. He is always poor, out of luck, and friendless."
Jones commented that nobody more perfectly described the coyote than Twain and decided to use some of his descriptions for the down-on-his-luck and starving Wile. E.
Wile. E Coyote's name is an appropriate pun on the word "wily," meaning to be cunning and crafty. However, few people know that the "E" in his name is said to stand for "Ethelbert" as was revealed in one issue of Looney Tunes & Merrie Melodies Comics.
Nevertheless, the cartoonist that included this information did not intend for it to be continuous with the show and is therefore considered to be non-canon. Regardless, many still accept Ethelbert to be his middle name.